diff --git a/python-checks/src/main/resources/org/sonar/l10n/py/rules/python/Agent_quality_profile.json b/python-checks/src/main/resources/org/sonar/l10n/py/rules/python/Agent_quality_profile.json
new file mode 100644
index 000000000..e077650fc
--- /dev/null
+++ b/python-checks/src/main/resources/org/sonar/l10n/py/rules/python/Agent_quality_profile.json
@@ -0,0 +1,220 @@
+{
+  "name": "Agent Quality Profile",
+  "ruleKeys": [
+    "S104",
+    "S1045",
+    "S107",
+    "S108",
+    "S1142",
+    "S1143",
+    "S1172",
+    "S1244",
+    "S134",
+    "S138",
+    "S1523",
+    "S1656",
+    "S1700",
+    "S1716",
+    "S1717",
+    "S1751",
+    "S1763",
+    "S1764",
+    "S1862",
+    "S2053",
+    "S2068",
+    "S2077",
+    "S2115",
+    "S2159",
+    "S2190",
+    "S2201",
+    "S2245",
+    "S2257",
+    "S2275",
+    "S2612",
+    "S2711",
+    "S2712",
+    "S2733",
+    "S2734",
+    "S2755",
+    "S2757",
+    "S2823",
+    "S2876",
+    "S3329",
+    "S3358",
+    "S3403",
+    "S3699",
+    "S3776",
+    "S3827",
+    "S3862",
+    "S3923",
+    "S3981",
+    "S3984",
+    "S3985",
+    "S4143",
+    "S4423",
+    "S4426",
+    "S4433",
+    "S4502",
+    "S4721",
+    "S4784",
+    "S4787",
+    "S4790",
+    "S4792",
+    "S4823",
+    "S4828",
+    "S4829",
+    "S4830",
+    "S5042",
+    "S5247",
+    "S5300",
+    "S5332",
+    "S5344",
+    "S5439",
+    "S5443",
+    "S5445",
+    "S5527",
+    "S5542",
+    "S5547",
+    "S5549",
+    "S5607",
+    "S5632",
+    "S5642",
+    "S5644",
+    "S5659",
+    "S5707",
+    "S5708",
+    "S5714",
+    "S5717",
+    "S5719",
+    "S5722",
+    "S5724",
+    "S5756",
+    "S5796",
+    "S5807",
+    "S5828",
+    "S5845",
+    "S5850",
+    "S5852",
+    "S5855",
+    "S5856",
+    "S5868",
+    "S5905",
+    "S5915",
+    "S5953",
+    "S5994",
+    "S5996",
+    "S6001",
+    "S6002",
+    "S6249",
+    "S6265",
+    "S6270",
+    "S6275",
+    "S6281",
+    "S6302",
+    "S6303",
+    "S6304",
+    "S6308",
+    "S6317",
+    "S6319",
+    "S6323",
+    "S6327",
+    "S6328",
+    "S6329",
+    "S6330",
+    "S6332",
+    "S6333",
+    "S6377",
+    "S6418",
+    "S6437",
+    "S6463",
+    "S6468",
+    "S6540",
+    "S6543",
+    "S6552",
+    "S6560",
+    "S6662",
+    "S6663",
+    "S6709",
+    "S6714",
+    "S6725",
+    "S6727",
+    "S6729",
+    "S6734",
+    "S6735",
+    "S6740",
+    "S6741",
+    "S6779",
+    "S6781",
+    "S6785",
+    "S6786",
+    "S6799",
+    "S6863",
+    "S6882",
+    "S6883",
+    "S6887",
+    "S6890",
+    "S6894",
+    "S6900",
+    "S6903",
+    "S6908",
+    "S6911",
+    "S6918",
+    "S6919",
+    "S6925",
+    "S6928",
+    "S6929",
+    "S6971",
+    "S6972",
+    "S6973",
+    "S6974",
+    "S6978",
+    "S6982",
+    "S6984",
+    "S6985",
+    "S7483",
+    "S7484",
+    "S7487",
+    "S7488",
+    "S7489",
+    "S7490",
+    "S7493",
+    "S7497",
+    "S7499",
+    "S7501",
+    "S7502",
+    "S7506",
+    "S7507",
+    "S7514",
+    "S7515",
+    "S7608",
+    "S7609",
+    "S7613",
+    "S7617",
+    "S7618",
+    "S7619",
+    "S7620",
+    "S7621",
+    "S7625",
+    "S7931",
+    "S7932",
+    "S7942",
+    "S7943",
+    "S8370",
+    "S8371",
+    "S8374",
+    "S8375",
+    "S8385",
+    "S8389",
+    "S8392",
+    "S8396",
+    "S8400",
+    "S8401",
+    "S8405",
+    "S8409",
+    "S8411",
+    "S8414",
+    "S905",
+    "S930",
+    "S935"
+  ]
+}
\ No newline at end of file
diff --git a/python-commons/src/main/java/org/sonar/plugins/python/PythonAgentQualityProfile.java b/python-commons/src/main/java/org/sonar/plugins/python/PythonAgentQualityProfile.java
new file mode 100644
index 000000000..c21fa6a77
--- /dev/null
+++ b/python-commons/src/main/java/org/sonar/plugins/python/PythonAgentQualityProfile.java
@@ -0,0 +1,60 @@
+/*
+ * SonarQube Python Plugin
+ * Copyright (C) 2011-2025 SonarSource Sàrl
+ * mailto:info AT sonarsource DOT com
+ *
+ * This program is free software; you can redistribute it and/or
+ * modify it under the terms of the Sonar Source-Available License Version 1, as published by SonarSource SA.
+ *
+ * This program is distributed in the hope that it will be useful,
+ * but WITHOUT ANY WARRANTY; without even the implied warranty of
+ * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.
+ * See the Sonar Source-Available License for more details.
+ *
+ * You should have received a copy of the Sonar Source-Available License
+ * along with this program; if not, see https://sonarsource.com/license/ssal/
+ */
+package org.sonar.plugins.python;
+
+import org.sonar.api.server.profile.BuiltInQualityProfilesDefinition;
+import org.sonar.plugins.python.editions.RepositoryInfoProvider;
+import org.sonar.plugins.python.editions.RepositoryInfoProvider.RepositoryInfo;
+import org.sonarsource.analyzer.commons.BuiltInQualityProfileJsonLoader;
+
+/**
+ * Agent Quality Profile - Built-in profile focused on security, reliability, and code complexity
+ *
+ * This profile activates rules that help maintain code quality for AI agents by focusing on:
+ * - Security vulnerabilities and security hotspots
+ * - Reliability issues (bugs)
+ * - Code complexity metrics (cognitive complexity, cyclomatic complexity, etc.)
+ */
+public class PythonAgentQualityProfile implements BuiltInQualityProfilesDefinition {
+
+  static final String PROFILE_NAME = "Agent Quality Profile";
+  static final String AGENT_PROFILE_LOCATION = "org/sonar/l10n/py/rules/python/Agent_quality_profile.json";
+
+  private final RepositoryInfoProvider[] editionMetadataProviders;
+
+  public PythonAgentQualityProfile(RepositoryInfoProvider[] editionMetadataProviders) {
+    this.editionMetadataProviders = editionMetadataProviders;
+  }
+
+  @Override
+  public void define(Context context) {
+    NewBuiltInQualityProfile profile = context.createBuiltInQualityProfile(PROFILE_NAME, Python.KEY);
+
+    for (RepositoryInfoProvider repositoryInfoProvider : editionMetadataProviders) {
+      registerRulesForEdition(repositoryInfoProvider, profile);
+    }
+
+    profile.done();
+  }
+
+  private static void registerRulesForEdition(RepositoryInfoProvider repositoryInfoProvider, NewBuiltInQualityProfile profile) {
+    RepositoryInfo repositoryInfo = repositoryInfoProvider.getInfo();
+    // Load the Agent Quality Profile instead of Sonar way profile
+    BuiltInQualityProfileJsonLoader.load(profile, repositoryInfo.repositoryKey(), AGENT_PROFILE_LOCATION);
+    profile.activeRules().removeIf(rule -> repositoryInfo.disabledRules().contains(rule.ruleKey()));
+  }
+}
diff --git a/python-commons/src/main/java/org/sonar/plugins/python/PythonExtensions.java b/python-commons/src/main/java/org/sonar/plugins/python/PythonExtensions.java
index bd67a8950..4145c3d30 100644
--- a/python-commons/src/main/java/org/sonar/plugins/python/PythonExtensions.java
+++ b/python-commons/src/main/java/org/sonar/plugins/python/PythonExtensions.java
@@ -76,6 +76,7 @@ public static void addCommonExtensions(Plugin.Context context) {
 
       Python.class,
       PythonProfile.class,
+      PythonAgentQualityProfile.class,
 
       PythonSensor.class,
       PythonRuleRepository.class,